So far,Chrome browser is still not certified by Oracle Application, so you can not access Oracle Apps via Chrome.But you can install a chrome Extension to access Oracle Application(It works fine for 11i or R12 instance)

Chrome Plugin:Oracle EBS R12 Enablement for Chrome

You can use this Chrome Extension to log in Oracle E-Business R12 Form UI without FRM-92129(or FRM-92120) error which say the file Registry.dat lost.

Plugin Author: zorrofox
(see:http://www.itpub.net/forum.php?mod=viewthread&tid=1724526&page=1#pid20409128)